Open access
Aug 2026
A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis
Lysosomes make key contributions to the maintenance of cellular proteostasis, and their functional compromise has been linked to aging and neurodegenerative disease. A defining characteristic of lysosomes is their relative acidity compared to other subcellular compartments, a quality that enables the efficient breakdow...
Mackenzie Welch, Paul J. Sampognaro, Shun-Pan Shu et al.
· bioRxiv · 0 citations