Joanna Y. Kim

A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy

A fully human sequence-based cell therapy suicide switch based on the overexpression of Caspase-Activated DNase and its stoichiometric chaperone/inhibitor ICAD fused to a lenalidomide-inducible degron achieved long-term expression in primary human T cells without detectable leakiness, and deep drug-induced cell depleti...