Joan M. O’Brien

Experimental models to study oxidative stress in glaucoma: integrating in vitro, in vivo, and clinical studies

Glaucoma is a complex optic neuropathy and the leading cause of permanent blindness worldwide. Elevated intraocular pressure (IOP) is the major modifiable risk factor for this disease. Growing evidence suggests that oxidative stress and reactive oxygen species (ROS) are key mediators of retinal ganglion cell (RGC) deat...