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Jiyong Hong

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Open access Aug 2026

A cholinergic hub in the nucleus accumbens gates opioid-reward learning

Beneficial and maladaptive opioid effects are difficult to dissociate, partly because dopamine signaling contributes to both. Here we show that associative opioid-reward learning can be blocked even under conditions that elevate dopamine in the nucleus accumbens. We developed naloxoneDART, a cell-type-specific analogue...

S. Yousefzadeh, Haidun Yan, Seung‐Hwa Kwak et al. · 1 citation
#protein folding Open access Aug 2026

The KRASG12C Inhibitor Divarasib Stabilizes RBM39 and Antagonizes Aryl-Sulfonamide Degraders

Using stability-based proteomics, this study shows how protein folding stability-based profiling can expand the actionable target landscape of small molecules beyond canonical covalent interactions, uncovering noncovalent off-targets that may underlie response heterogeneity and treatment-associated toxicity.

Ssu-Yu Chen, Y. Zou, Jianli Wu et al. · 0 citations

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