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Author

Jinyu Chen

2 papers indexed here

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Open access Sep 2026

Membranes Decouple α-Synuclein Surface Assembly and Kinetic Restriction from Persistent Amyloid-like Intermolecular Organization

Membrane association places α-synuclein (αSyn) at the boundary between physiological surface organization and pathological amyloid assembly, supporting vesicle clustering, surface condensation, and amyloid nucleation. How interfacial recruitment, condensate cohesion, and persistent amyloid-like organization are coupl...

Jin-Yu Chen, Xia-Kun Chu · 0 citations
Open access Aug 2026

Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

A two-layer regulatory mechanism in which phosphorylation rewires IDR electrostatics while pocket-binding ligands redirect folded-domain interactions is revealed, suggesting a strategy for modulating multidomain condensates through ligand-induced contact-network remodeling.

Yu Cao, Jin-Yu Chen, Xia-Kun Chu · 0 citations

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