Jintao Feng

Self-Assembly of Virus-like Nanoparticles for Nucleic Acid Delivery Based on De Novo Designed α-Helix Peptides.

Efficient and safe delivery of nucleic acids remains a major challenge for clinical translation of gene therapies. Here, we report de novo-designed α-helical peptides that coassemble with lipids and nucleic acids to form core-shell, virus-like nanoparticles (VLNs). The peptides combine a cationic N-terminus for nucleic...