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In adults with moderate sensorineural hearing loss, a down-sloping audiometric configuration was associated with greater improvement in speech intelligibility following HA fitting than a flat audiometric configuration.
Initial amplification accuracy, particularly at high frequencies, plays a critical role in long-term hearing aid fitting stability, and achieving sufficient gain at 6000 Hz during the first fitting session may improve long-term fitting outcomes and reduce suboptimal hearing aid use.
PURPOSE OF REVIEW This review summarizes nonviral genome-editing delivery platforms for hereditary hearing loss, focusing on lipid nanoparticles (LNPs) and engineered virus-like particles (eVLPs), and discusses their advantages over adeno-associated virus-based delivery, as well as the barriers to clinical translation....
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