Open access
Aug 2026
Pocket-PROTACs: an interpretable pocket-aware deep learning framework for predicting PROTAC-induced protein degradation
Pocket-PROTACs is proposed, a pocket-aware attention-based framework for predicting PROTAC-induced protein degradation from a triplet of POI, E3 ligase, and PROTAC, which consistently outperforms fingerprint-based baselines and recent deep learning methods.
Kai Chen, Zhijian Huang, Yinbo Wang et al.
· Bioinformatics · 0 citations