Sirtuin five knockdown induced the ferroptosis of hepatic stellate cells in hepatic fibrosis progression through de-succinylation modification of GPX4
Hepatic fibrosis results from persistent pathological damage and repair following various chronic liver injuries. In this study, we explored the specific mechanism of sirtuin 5 (SIRT5) in the development of hepatic fibrosis. Transforming growth factor-beta 1 (TGF-β1)-treated LX-2 cells and CCl4-treated mice were used t...