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Jinhong Xie

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#protein folding Open access Oct 2026

Triazole Stress Induces Accelerated Degradation of Aspergillus fumigatus Hmg1

Triazole antifungals inhibit the lanosterol C14-demethylase Cyp51A/B and are the first-line treatment for invasive aspergillosis caused by Aspergillus fumigatus. We previously proposed that triazoles impose a secondary constraint on ergosterol biosynthesis through negative feedback regulation of HMG-CoA reductase (Hmg1...

Jinhong Xie, Adela Martín‐Vicente, Harrison I. Thorn et al. · 0 citations

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