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Author

Jingru Wang

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Open access Aug 2026

TDP-43 drives ferroptosis evasion by modulating PCBP1/PCBP2 axis to promote lung adenocarcinoma growth

Lung adenocarcinoma (LUAD) continues to be one of the top causes of cancer-associated deaths worldwide. TAR DNA-binding protein 43 (TDP-43) has been linked to several tumor-related biological processes, yet its specific role in LUAD growth remains poorly understood. Ferroptosis, an iron-dependent regulated cell death,...

Bo-Wen Liu, Xin Chen, Jingjing Chen et al. · 0 citations
Aug 2026

BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts.

Multivesicular bodies (MVBs) contain intraluminal vesicles (ILVs) designated for degradation in lysosomes or release as exosomes for cell-to-cell communication. The mechanisms governing ILV/exosome formation are not fully understood. Here, we show that the integral endoplasmic reticulum (ER) membrane protein bridge-lik...

Jingru Wang, Dongchen Li, Yazhou Liu et al. · 0 citations

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