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Jingjing Chen

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Open access Aug 2026

TDP-43 drives ferroptosis evasion by modulating PCBP1/PCBP2 axis to promote lung adenocarcinoma growth

Lung adenocarcinoma (LUAD) continues to be one of the top causes of cancer-associated deaths worldwide. TAR DNA-binding protein 43 (TDP-43) has been linked to several tumor-related biological processes, yet its specific role in LUAD growth remains poorly understood. Ferroptosis, an iron-dependent regulated cell death,...

Bo-Wen Liu, Xin Chen, Jingjing Chen et al. · 0 citations
Open access Aug 2026

Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders

LD5095 demonstrates potent and selective RIPK1 degradation across cell lines, with rapid kinetics and sustained degradation over 72h post-washout, and exhibited favorable pharmacokinetics, including metabolic stability and an extended half-life.

Dong Lu, Xin Yu, Han-Qing Lin et al. · 1 citation

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