Open access
2026
Dual-dynamic control and metabolic rebalancing guided by toxic target discovery for efficient dencichine production
A growth-phase-dependent dual-dynamic regulation circuit is developed that gradually activates serA expression and progressively represses serB expression as cells enter the stationary phase, thereby reducing 2-HG accumulation and alleviating L-serine auxotrophy.
Yu Zhang, Jun Wu, Jinghua Yu et al.
· The Innovation Life · 0 citations