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Author

Jingchen Zhu

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Review Open access 2026

Artificial intelligence in the rational design of lipid nanoparticles for mRNA therapeutics

This review surveys how artificial intelligence is converting this nonlinear design space from empirical iteration into data-efficient, multi-objective optimization and outlines three priorities for translation: standardized data and metadata, mechanistic endpoints for escape and immunogenicity, and CMC-aware optimization.

Heyu Zhao, Junchao Xu, Xia Gao et al. · 2 citations

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