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Author

Jing Yuan

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Open access Aug 2026

Coxiella burnetii inhibits host cell death by ubiquitination‐induced inactivation of an apoptosis nuclease

Abstract Coxiella burnetii modulates a variety of host cell processes to create a niche permissive for its intracellular replication using effectors injected by its Dot/Icm type IV secretion system. More than 130 such effectors have been identified, but the function of most of them remains unknown. Using an activity‐ba...

Yong Zhang, J. Jiao, Shuxin Liu et al. · 0 citations
Aug 2026

Immunogenicity and post-challenge virological outcomes of a multivalent subunit vaccine in sheep challenged with cytopathic BVDV-1a.

The findings show that CSV induced measurable immune responses and was associated with lower whole-blood BVDV RNA loads during the 2-week post-challenge observation period, which supports the feasibility of a multivalent combination strategy for BVDV subunit vaccine development.

Zhi-Ran Shao, Jing Yuan, Yu-Hao Li et al. · 0 citations

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