Open access
Jul 2026
DCAF13: a positive regulator of colon cancer cell proliferation via the AMER2/ Wnt/β-catenin pathway.
In colon cancer cells, DCAF13 regulated adenomatous polyposis coli membrane recruitment 2 (AMER2) through ubiquitination, DCAF13 deletion increased AMER2 expression, which inhibited Wnt/β-catenin activity, suppressing cell proliferation, and this effect was further validated in mice with gut-specific DCAF13 knockout.
Yu-Xin Hua, Jie Gao, Qing Sun et al.
· npj Precision Oncology · 0 citations