Jing-Ying Liu

Discovery of a novel BRD4 inhibitor for the treatment of acute myeloid leukemia.

Bromodomain-containing protein 4 (BRD4), an epigenetic regulatory reader, is closely related to the development of various cancers, so it has emerged as one of the most extensively investigated therapeutic targets for tumors. However, no BRD4 inhibitors have received clinical approval to date, underscoring the signific...