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Author

Jing Wen

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Open access Sep 2026

Integrative genetic analyses of circadian chronotype and autism highlight regional co-association at 17q21.31.

Chronotype and sleep problems are common in autism spectrum disorder (ASD), but their genetic relationship remains uncertain. We integrated published cross-trait LD score regression (LDSC), brain eQTL-based summary-data-based Mendelian randomization (SMR), SNP-based two-sample MR, two-step mediation MR, secondary paral...

Jing Wen, Q. Pu · 0 citations
Jul 2026

NRXN1 haploinsufficiency converges on RNA processing during cortical development, with partial transcriptomic concordance in adult autism cortex.

NRXN1 haploinsufficiency is associated with coordinated downregulation of RNA-processing genes in cortical organoids, and the convergence on mRNA nuclear export and RNA-processing genes should be interpreted cautiously and verified by direct experimental perturbation.

Xi Lai, Jing Wen · 0 citations

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