Sep 2026
A novel mTORC1-NPC2 axis suppresses lipophagy and drives atherosclerotic plaque progression.
BACKGROUND Endothelial dysfunction is a critical initiating factor in atherosclerosis (AS), with NPC2 and mTORC1 playing key roles in the regulation of endothelial lipophagy. OBJECTIVE To reveal that hypercholesterolemia disrupts endothelial lipophagy via the mTORC1-NPC2 axis and to explore its role in atheroscleroti...
Le-Gao Chen, Wei-Qin Lu, Long Piao et al.
· Biochimica et Biophysica Act... · 0 citations