Review
Sep 2026
Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS/MAM): Multi-Layered Upstream Regulators of Microglial Senescence in Alzheimer's Disease.
Overall, MERCS dysfunction is proposed as a candidate multimodal upstream hub for calcium, mitochondrial, inflammatory, lipid and ER-stress signalling, and rigorous in-vivo validation together with microglia-selective delivery platforms is essential for therapeutic translation.
An-Nan Liu, Li-Ping Xing, Jian-Hui Li et al.
· Ageing Research Reviews · 0 citations