PDCD4-driven steatosis via the HNF4A/GK axis is attenuated by the natural compound isosinensetin.
BACKGROUND Programmed cell death factor 4 (PDCD4) has been implicated in various metabolic disorders. However, its role and underlying mechanisms in metabolic dysfunction-associated steatotic liver disease (MASLD) have not been fully elucidated. PURPOSE This study aimed to define the role of PDCD4 in hepatic steatosi...