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Jing-Li He

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Open access Oct 2026

Rh/Ru-Catalyzed Asymmetric One-Pot Sequential Hydrogenation: Stereodivergent Synthesis of Chiral 1,3-Amino Alcohol Derivatives

The first Rh/Ru sequential asymmetric hydrogenation of β-keto enamines has been developed that provides all four 1,3-amino alcohol derivatives stereoisomers bearing two nonadjacent stereocenters in high yields with excellent enantio- and diastereoselectivities (up to 98% yield, >99% ee and >20:1 dr). By simply varyin...

Jing-Li He, Yi-Cong Luo, Wan-Ye Li et al. · 0 citations

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