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Author

Jing Li

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Open access Aug 2026

Maternal obesity programs offspring metabolic dysfunction via small extracellular vesicle-mediated epigenetic remodeling

It is shown that maternal circulating small extracellular vesicles crossed the placenta and delivered obesity-associated miRNAs to the fetal liver, with lasting consequences for insulin sensitivity in male offspring, and a transplacental sEV-miRNA-epigenetic axis is identified as a mediator of maternal obesity.

Hui-Chen Song, Dameng Li, Li-Na Ma et al. · 0 citations
Aug 2026

Co-evolution-guided engineering of monensin biosynthetic monooxygenase MonCI reveals mechanistic basis for concurrent stability and catalytic enhancement.

Improving enzyme stability without compromising catalytic activity remains a major challenge in protein engineering. Here, we present a co-evolution-guided strategy to enhance both thermostability and catalytic performance of the flavin-dependent monooxygenase MonCI, an enzyme involved in monensin biosynthesis. By comb...

Hongli Xiao, Jing Li, Jiajie Zhou et al. · 0 citations

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