SUMMARY Immunity requires a delicate balance between combating infection and preserving metabolic functions. However, the mechanisms by which immune responses are coordinated with cellular metabolism remain largely unknown. Here, we show that NONEXPRESSER OF PR GENES 1 (NPR1), the central plant immune regulator of sali...
Yi-Xuan Chen, J. Withers, Yu-Lin Sun et al.· Cell· 0 citations
Sesquiterpenoid chemical diversity is frequently generated through cytochrome P450 (CYP)-mediated oxidation of terpene scaffolds. In Medicago truncatula, the sesquiterpene alcohol himachalol, produced by the terpene synthase MtTPS10, has been implicated in pathogen defense, yet the enzymes responsible for its downstrea...
Jessie A. Dorff, Priyanka Gupta, Fu-Shuang Li et al.· Plant physiology and biochem...· 0 citations
The crystal structure of Petunia hybrida BS is reported, which reveals an α2β2 heterotetrameric arrangement, establishing BS as a rare heterotetrameric plant SDR and demonstrating how subunit specialization and intersubunit arrangement enable function, providing principles for understanding and engineering multimeric e...
Jason O. Matos, Jihee Lee, Ramasamy P. Kumar et al.· Science Advances· 0 citations
Boltz2ESI is introduced, an end-to-end framework that predicts enzyme–substrate interactions by leveraging structural knowledge learned by a biomolecular foundation model and consistently outperforms state-of-the-art sequence-based and rigid-docking approaches.
Xi-Wei Cheng, Seonghwan Seo, C. Huh et al.· bioRxiv· 0 citations
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