The cGAS-STING pathway is a fundamental cytosolic DNA-sensing mechanism that activates innate immune responses through the production of type I interferons (IFNs) and other cytokines. Autophagy, a conserved intracellular degradation system, plays crucial roles in maintaining cellular homeostasis by clearing damaged o...
Dan-Dan Ye, Qiong Li, Amit Sharma et al.· Molecular Medicine· 0 citations
Introduction While genetic abnormalities underlying lymphoid malignancies (LM) are well-characterized, the environmental and metabolic determinants driving LM remain largely unexplored. Autoimmune diseases are known risks, yet the specific circulating mediators and potential protective dietary factors linking these con...
Dong-Guo Liang, Yan Ren, Yu-Qi Feng et al.· Frontiers in Immunology· 0 citations
How dysregulated palmitoyltransferases and depalmitoylases modify metabolic enzymes, lipid transporters, lipid-droplet proteins, oncogenic signaling components, and immune-regulatory molecules creates self-reinforcing circuits that sustain tumor growth and treatment failure is reviewed.
Qian Zhao, Jian-Gang Mei, Si-Qi Qian et al.· Frontiers in Immunology· 0 citations
G2 is established as a promising therapeutic candidate for surmounting sorafenib resistance, characterized by selective antitumor activity against malignant hepatocellular carcinoma.
Keyan Han, Yuqi Lin, Yu Huang et al.· European journal of medicina...· 0 citations
This review comprehensively highlights the latest advancements in using nanotechnology to enhance cancer immunotherapy and highlights synergistic effects achieved by combining nanoparticles with other treatments like chemotherapy, radiation, photothermal/photodynamic therapy, and more, which can turn hard-to-treat tumo...
U. Cho, Jing-Jing Pu, Amit Sharma et al.· Molecular Cancer· 0 citations
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