Histone demethylase JMJD2D promotes macrophage IL-12b expression and contributes to host defense against Listeria monocytogenes infection.
Introduction Listeria monocytogenes (L. monocytogenes) is an intracellular bacterial pathogen that requires coordinated innate and adaptive immune responses for effective clearance. However, the epigenetic mechanisms governing host defense against L. monocytogenes remain poorly understood. Methods JMJD2D-deficient mi...