Open access
Jul 2026
IgGM2: An All-Atom Foundation Model for Adaptive Immune Receptor Design
IgGM2 follows a structure-to-design strategy: it first learns how immune receptors are positioned around fixed target structures, and then transfers this target-conditioned structural prior to CDR design, allowing frame-work geometry to adapt to designed CDRs without separate inverse folding or external sidechain packing.
Jian Ma, Fandi Wu, Lin Yao et al.
· bioRxiv · 0 citations