Dual-restricted AAV gene delivery via suprachoroidal administration mediates precision RPE SOCS3 restoration for dry age-related macular degeneration.
A dual-restricted ocular gene delivery platform that combines suprachoroidal administration with an RPE-specific Best1 promoter enables localized, durable, and cell-restricted SOCS3 expression, supporting suprachoroidal AAV-Best1-SOCS3 delivery for localized modulation of oxidative-inflammatory retinal degeneration.