Aug 2026
Reprogramming of lipid metabolism by PFKL promotes the adaptation of pancreatic ductal adenocarcinoma to glucose deprivation.
BACKGROUND/OBJECTIVE Lipid droplet (LD)-mitochondria tethering is essential for fatty acid oxidation (FAO), which sustains tumor cell survival under nutrient-deprivation conditions. However, how LD-mitochondria contact is regulated in pancreatic ductal adenocarcinoma (PDAC) is unclear. METHODS This study investigated...
Lu Chai, Zhaoyuan Meng, Zhi-Min Lu et al.
· Cellular Signalling · 0 citations