Open access
Aug 2026
Engineered probiotic Escherichia coli Nissle 1917 delivery of GPX4 suppresses pyroptosis and protects against sepsis
Sepsis remains a leading cause of mortality worldwide, driven by dysregulated inflammation and organ failure, with limited targeted therapies. Pyroptosis, mediated by gasdermin D (GSDMD), amplifies sepsis pathology through lipid peroxidation-dependent mechanisms, yet direct interventions are scarce. Leveraging the...
Hao Wang, Jinsong Zhang, Wen Li et al.
· Food Science and Human Welln... · 0 citations