tsRNAs Mediate Intergenerational Inheritance by Concertedly Suppressing Wnt and PPAR Pathways.
OBJECTIVE The Developmental Origins of Health and Disease hypothesis posits that paternal environmental exposures program offspring metabolic health via sperm epigenetic factors, particularly tRNA-derived small RNAs (tsRNAs). Cadmium (Cd) is a ubiquitous environmental pollutant known to impair reproductive health, but...