Author

Jin-Yi Liu

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Open access Oct 2026

Hypoxia-inducible CEA-targeted CAR T-cell therapy for relapsed stage IV non-small cell lung cancer.

Mitigating on-target off-tumor toxicity remains a central challenge for chimeric antigen receptor (CAR) T-cell therapy for solid tumors. We developed a hypoxia-inducible CAR-T-cell product targeting carcinoembryonic antigen (CEA) that restricts CAR activation to hypoxic tumor niches via oxygen-dependent expression cont...

Shuang Wei, Jia-Qi Guo, Xue-Li Bai et al. · Cancer Discovery · 0 citations

Sep 2026

Prediction of the Efficacy of PA-TACE in Patients with Clearly Defined Hepatocellular Carcinoma by Imaging Combined with Serology: A Retrospective Cohort Study with a Two-Center Follow-Up of up to 12 Years.

OBJECTIVE The purpose of this study was to determine which patients with hepatocellular carcinoma (HCC) actually benefit from Postoperative adjuvant Transarterial chemoembolization (PA-TACE) and to develop a reliable predictive model for tailored treatment choices. METHODS A total of 150 HCC patients received PA-TACE...

Jin-Yi Liu, Qiang Xu, Qian Song et al. · Cancer Biotherapy and Radiop... · 0 citations