Reprogramming the Aging Type H Vascular Niche via Myeloid Angiogenic Cell-Derived Extracellular Vesicles: Mechanisms, Engineering Strategies, and Translational Perspectives
This review synthesizes current evidence on endothelial EV cargo and discusses how aging remodels vesicle composition and function to drive vascular–bone uncoupling, and compares bioengineering strategies aimed at correcting senescence-associated cargo liabilities and improving translational readiness.