Glucose-Functionalized Piperlongumine-Encapsulated Nanoparticles Selectively Target Schistosomal Tegument and Enhance the Anti-schistosomiasis Effect
The therapeutic potential of piperlongumine (PL) against schistosomiasis and hepatic injury is limited by its poor water solubility. Herein, well-defined, monodisperse, surface glucose-functionalized, and PL-encapsulated nanoparticles (PL-NPs) with uniform size (hydrodynamic diameter: ∼264 nm) were synthesized via a...