Open access
Sep 2026
Engineering the chimeric lysin Art-15 via NZ2114–PlySs2 fusion enhances strain-specific antibacterial activity
The global rise of multidrug-resistant Gram-positive pathogens demands new antimicrobial strategies. Phage-derived endolysins such as PlySs2 show promising cell-wall targeting activity but may be limited by strain-dependent cell-envelope accessibility. We engineered Art-15, a chimeric lysin that fuses the lipid II-targ...
Meng-Lin Lee, Zhi-Tao Wu, Xing-Yu Zhou et al.
· Microbes & Immunity · 0 citations