Author

Jin-Lin Zhang

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Sep 2026

Discovery of 3-Carboxyl-4-pyrazolamides as Promising Herbicidal Scaffolds Targeting Dihydroorotate Dehydrogenase

Enhancing innovation in herbicide discovery is imperative to combat weed resistance and safeguard global food security. To develop novel herbicide targeting dihydroorotate dehydrogenase (DHODH), a series of 3-carboxy-4-pyrazole amide lead scaffold bearing ester or acid substituents were designed and synthesized. Bioa...

Zhao-Rui Wang, Ya-Ze Li, Ji-Peng Zhang et al. · Journal of Agricultural and... · 0 citations

Jul 2026

Design, Synthesis, and Herbicidal Activity of Indole-Containing Fusarium Acid Derivatives Targeting Transketolase.

Transketolase (TKL; EC 2.2.1.1) has been validated as a potential new herbicide target. To develop a new and highly effective herbicides-targeted TKL, a series of indole-containing fusarium acid (FA) derivatives 9a-9s were designed and synthesized. Among them, compound 9o exhibited more excellent herbicidal activity ag...

Cheng-Kun Li, Yong-Qi Liu, Xizheng Ma et al. · Journal of Agricultural and... · 0 citations

Jul 2026

Discovery of Pyrazole-Fusaric Acid Derivatives as the Potential Herbicidal Lead Compounds Targeting Both Transketolase and Protoporphyrinogen Oxidase.

Transketolase (TKL, EC 2.2.1.1) was confirmed as a potential new target for herbicides. In this study, a series of pyrazole-fusaric acid derivatives 9a-9o were designed and synthesized via structural optimization of compound 7r. Among them, compound 9f exhibited good inhibition on Digitaria sanguinalis and Amaranthus r...

Yong-Qi Liu, Cheng-Kun Li, Xizheng Ma et al. · Journal of Agricultural and... · 0 citations