Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15–ATP4B axis in renal cell carcinoma
Highlights • Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a previously unrecognized tumor suppressor in renal cell carcinoma.• LMX1B-associated epithelial cells function as central signaling hubs within the tumor microenvironment, engaging in spatially organized bidirectional communicat...