Jin-Hui Feng

Unlocking a Peroxidation Activity of Ketosteroid Isomerase with Ferrocenes as an Electron Mediator

Enzymatic direct hydroxylation of steroid skeletons is vital for generation of physiologically and pharmacologically valuable compounds due to their structural and functional diversity. In this study, we discovered that ketosteroid isomerase (KSI) exhibited peroxidation activity using ferrocene and its analogues as e...

Manipulating activity and chemoselectivity of a benzaldehyde lyase to synthesize α-hydroxyketones.

[Directed evolution of amine dehydrogenase for the catalytic resolution of (1R,5S)-3-ethylbicyclo [3.2.0] hept-3-en-6-one, a chiral intermediate of mirogabalin].