Author

Jin-Gen Li

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Review Open access Jul 2026

AI-enabled fungal biomanufacturing: from genome mining to the artificial intelligence virtual cell

ABSTRACT Fungi are important chassis organisms for sustainable biomanufacturing owing to their strong secretion capacity, metabolic diversity, and adaptability to industrial processes. Driven by the rapid development of Artificial Intelligence (AI), computational approaches that enable machines to learn patterns from d...

Zhi-Xuan Wang, Xuan-Ye Chen, Shu-Ying Gu et al. · Mycology · 0 citations

Sep 2026

Metabolic Engineering of the Thermophilic Fungus Myceliophthora thermophila for l -glutamate Production from Lignocellulosic Biomass

l-Glutamic acid is conventionally produced by bacteria from starch-derived sugar, while its production in eukaryotic hosts remains rarely reported. The thermophilic ascomycete fungus Myceliophthora thermophila has been developed as a platform for producing value-added chemicals from lignocellulosic biomass. In this s...

De-Fei Liu, Yu-Tong Ge, Jin-Gen Li et al. · ACS Synthetic Biology · 0 citations

Open access Aug 2026

Unlocking raw-corncob consolidated bioprocessing for malic acid production by DyP-enabled lignin deconstruction in Myceliophthora thermophila

l-Malic acid is an important C4 platform chemical, but its direct production from raw lignocellulosic biomass by consolidated bioprocessing (CBP) remains constrained by biomass recalcitrance. Here, we developed an integrated lignin-side and sugar-side engineering strategy in the thermophilic fungus Myceliophthora therm...

Yu-Ying Zhang, Yu-Han Zhang, Li-Kun Han et al. · Synthetic and Systems Biotec... · 0 citations