Author

Jin-Fa Wu

2 papers indexed here

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Open access Sep 2026

PLPP1 inhibits Wnt/β-catenin signaling via enhancing Caveolin-1/β-catenin interaction and is negatively regulated by c-Myc in osteosarcoma

Background Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents, characterized by rapid progression and poor prognosis. The molecular mechanisms underlying OS malignancy remain incompletely understood. Phospholipid phosphatase 1 (PLPP1) has recently been implicated in cancer biology, yet its...

Jiang-Bo Nie, Yang Zhou, Xin-Sheng Xie et al. · Journal of Orthopaedic Trans... · 1 citation

Sep 2026

DRAM1 activates microglial pyroptosis and neuroinflammation through TMEM9-mediated lysosomal membrane permeabilization after spinal cord injury.

Findings reveal that DRAM1 promotes microglial pyroptosis and neuroinflammation after SCI via the TMEM9-dependent induction of LMP and autophagic flux impairment, with its expression tightly regulated by IGF2BP3 in an m6A-dependent manner.

Zhi-Chao Xiong, Guang-Kui Yan, Jin-Fa Wu et al. · Cellular Signalling · 0 citations