Author

Jin Ding

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Open access Jul 2026

Tumor-derived annexin A1 drives lenvatinib resistance by regulating SOX2/STAT3/S100A6 feedback loop and M2 macrophage polarization in hepatocellular carcinoma

The critical role of HCC-derived ANXA1 regulates lenvatinib resistance both intrinsically and extrinsically is demonstrated, and Targeting the SOX2/ANXA1/STAT3/S100A6 positive loop may provide a novel therapeutic strategy for HCC treatment.

Catherine Yu Jia Gu, C. Leung, R. Leung et al. · Cell Death & Disease · 0 citations

Open access Jul 2026

AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling.

A novel metabolic-epigenetic mechanism whereby lactate modulates hepatocellular carcinoma sensitivity to targeted therapies through histone lactylation is delineated and suggests AARS1-H4K12la-RAPGEF3 axis may serve as an interventional target to overcome targeted drug resistance, offering a promising strategy to enhan...

Tanlun Zeng, Wanwan Zhu, Guanqun Sun et al. · Cell Death and Disease · 1 citation