Author

Jin-Cheng Ma

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Sep 2026

Xenocoumacin 1 from Xenorhabdus nematophila CB6-T2: Antibacterial Spectrum and Multi-Target Mode of Action against Ralstonia solanacearum K60-1

Xenocoumacin 1 (Xcn1), a dihydroisocoumarin-derived antimicrobial natural product from Xenorhabdus nematophila CB6-T2, exhibits broad-spectrum antifungal activity, yet its antibacterial mechanism remains unknown. This study evaluated the antibacterial spectrum of Xcn1 against 13 bacterial strains, with Ralstonia sola...

Liu Yang, Yanping Lei, Jin-Cheng Ma et al. · Journal of Agricultural and... · 0 citations

Sep 2026

An integrated engineering strategy enhances expression and activity of Pseudonocardia thermophila nitrile hydratase in Escherichia coli.

Nitrile hydratase is a key enzyme for nitrile-to-amide hydration under mild conditions, yet its application is limited by low heterologous expression, poor solubility, and suboptimal catalysis. Here, we present an integrated strategy to enhance expression, assembly, and function of Pseudonocardia thermophila NHase (PtN...

Xiao-Ling You, Yu-Qing Chen, Zi-Ying Tan et al. · International Journal of Bio... · 0 citations