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#artificial intelligence Open access Oct 2026

Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition

Abstract Artificial intelligence (AI) methods for proteins have advanced rapidly, improving structure prediction and design, particularly for de novo binders. However, most evaluations emphasize binding affinity rather than higher-order biological function. We present Bits to Binders , a global competition evaluating d...

Clayton W. Kosonocky, Alex M. Abel, Aaron L. Feller et al. · 1 citation
#protein folding Open access Sep 2026

Domain classification of archaeal proteomes reveals conserved fold repertoire

Archaea represent one of the three domains of cellular life and yet account for fewer than 1% of experimentally determined protein structures, leaving the extent of their structural novelty unknown. Here we present a systematic domain-level classification of 124,075 proteins from 65 archaeal classes spanning 21 phyla a...

R. Dustin Schaeffer, Jimin Pei, Rui Guo et al. · 0 citations

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