Open access
Jul 2026
Charged amino acid propensities and solubility: lysine is elevated at the termini of helices in E. coli proteins
Protein design protocols could improve solubility through targeting lysine enrichment in regions such as helical termini, in addition to the more conventional consideration of helix capping interactions.
Sifan Zhang, Jim Warwicker
· bioRxiv · 0 citations