Jieying Bi

Degree-ranked gene lists omit the cross-module connectors, and a partition-free centrality recovers them

Network centrality is the workhorse of gene prioritisation, yet what a ranking omits is rarely audited. Scoring each selection against an annotation-count-matched maximum-entropy reference—asking whether a selected gene set covers the genome’s functional space or collapses it-reveals that the criterion in standard use...