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Author

Jie Zhu

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2 papers indexed here

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Open access Aug 2026

Targeted phagocytosis of TNF-α by CAR macrophages restores immune homeostasis in arthritis

Under stimulation with synovial fluid from arthritis patients, anti-TNFα CAR-M decreased TNF-α and IL-6 levels and drove macrophages toward an M2-like anti-inflammatory state, significantly alleviating inflammatory activation, clinical symptoms, and joint pathologies.

Mei-Qi Wang, Jie Zhu, Chun-Yu Liu et al. · 0 citations
Open access Sep 2026

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

ABSTRACT The accumulation of mutant huntingtin (mHTT) aggregates drives the pathology of Huntington's disease (HD), yet therapies capable of distinguishing toxic species from wild‐type proteins remain elusive. Here, a synthetic gene circuit, termed ARAA, was engineered to couple the preferential recognition of aggregat...

Jie Zhu, Xi-Xiu Xie, Lei Li et al. · 0 citations

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