Design, synthesis, antifungal activity, and phloem mobility of novel aromatic amide phenylthiazole-4-carboxylic acid derivatives as potential succinate dehydrogenase inhibitors.
BACKGROUND Although succinate dehydrogenase inhibitors (SDHIs) display potent antifungal activity, the majority possess weak phloem mobility, limiting their efficacy against root and vascular diseases. To develop novel SDHI candidates with phloem mobility, 36 aromatic (heterocyclic) amide phenylthiazole-4-carboxylic ac...