Author

Jie Zhao

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Open access Sep 2026

A Nomogram Integrating Deep Learning and Immunoscore for Predicting Distant Metastasis and Prognosis in Rectal Cancer.

RATIONALE AND OBJECTIVES To evaluate the performance of nomogram integrating MRI-based deep learning (DL) and immunoscore (IS) for predicting distant metastasis (DM) and prognostic stratification in rectal cancer (RC). MATERIALS AND METHODS This retrospective single-center study included 306 RC patients (mean age, 59...

Hao Jiang, Miao Sun, Wei Guo et al. · Academic Radiology · 0 citations

Open access Aug 2026

Dabigatran Attenuates Osteoporosis by Balancing Osteoblastogenesis and Osteoclastogenesis by Targeting PRKAB1 and RELA

Imbalances between osteoblastogenesis and osteoclastogenesis represent the fundamental pathological feature of primary osteoporosis; however, safe and cost-effective therapies that simultaneously promote bone formation and suppress bone resorption are lacking. Given the central roles of runt-related transcription facto...

Fei-Yu Chen, Yi-Feng Shang, Kai-Wen Liu et al. · Research · 0 citations

Aug 2026

Terazosin Alleviates Apoptosis and Neuroinflammation in Cerebral Ischemia-reperfusion Injury via Activating the PI3K/AKT/mTOR Signaling Pathway.

BACKGROUND Ischemic stroke remains a major cause of disability and death worldwide, and effective neuroprotective treatments are urgently needed. This study investigated whether Terazosin (TZ), a clinically approved drug with neuroprotective potential, ameliorated Cerebral Ischemia-Reperfusion Injury (CIRI) and explore...

Lin-Lin Xie, Yu-Kun Ping, Jie Zhao et al. · Current Neuropharmacology · 0 citations