Simultaneous hydrophilic interaction liquid chromatography-tandem mass spectrometry quantification of serum neurotransmitters and related metabolites: Development, validation, and application to antenatal depression.
Serum neurotransmitter profiling is analytically challenging because the target panel includes highly polar compounds with markedly different ionization behaviors, while several catecholamine-related analytes are also susceptible to oxidation during thawing and handling. Here, we developed and validated a derivatizatio...