Jie-Wei Zhang

ESM2-Guided Context-Aware Annotation Completion Supplements Carbohydrate Metabolism Coverage in Silage Microbial Metagenomes

Context-Aware Annotation Completion (CAAC), a framework integrating ESM2 embeddings, genomic-neighborhood features, three-class classification, confidence-tiered neighbor voting, and Enzyme Commission (EC)-to-KEGG Orthology (KO) mapping, extends the enzyme-level interpretation of under-annotated silage metagenomes, while the inferred assignments remain computational predictions requiring experimental validation.